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| 苯并色烯类化合物合成方法的探讨 | |
| 引用本文： | 金劲松,宋森川,林伟忠,黎逢权,陈国强,李红山,宋化灿. 苯并色烯类化合物合成方法的探讨[J]. 中山大学学报(自然科学版), 2009, 48(2) |
| 作者姓名： | 金劲松 宋森川 林伟忠 黎逢权 陈国强 李红山 宋化灿 |
| 作者单位： | 1. 广东中烟工业有限责任公司,广东,广州,510610;中山大学化学与化学工程学院,广东,广州,510275 2. 嘉应学院化学系,广东,梅州,514015 3. 中山大学化学与化学工程学院,广东,广州,510275 |
| 基金项目： | 广东省科技厅科技计划，国家重点实验室开放课题 |
| 摘 要： | 以取代苯甲醛、丙二腈和2-萘酚（或2,7-萘二酚）为原料合成出了3-氨基-2-氰基-1-(4-取代苯基)-1H-苯并［f］色烯类物质，后者在冰醋酸或者醋酸钠催化作用下，乙酸酐中回流，合成出苯并色烯并嘧啶类化合物。这类化合物的关环反应条件易于实施，后处理简单，易于纯化，属于首次报道。 |
| 关 键 词： | 合成 苯并［f］色烯类化合物 苯并［f］色烯并嘧啶类化合物 |
| 收稿时间： | 2008-11-25; |
The Exploration of the Synthetic Method for Benzochromenopyrimidine Derivatives |
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| JING Jinsong,SONG Senchuan,LIN Weizhong,LI Fengquan,CHEN Guoqiang,LI Hongshan,SONG Huacan. The Exploration of the Synthetic Method for Benzochromenopyrimidine Derivatives[J]. Acta Scientiarum Naturalium Universitatis Sunyatseni, 2009, 48(2) | |
| Authors: | JING Jinsong SONG Senchuan LIN Weizhong LI Fengquan CHEN Guoqiang LI Hongshan SONG Huacan |
| Affiliation: | (1. China Tobacco Guangdong Industrial Corporation Limited,Guangzhou 510610,China；2.School of Chemistry and Chemical Engineering,Sun Yat sen University,Guangzhou 510275,China3. Department of Chemistry,Jiaying University, Meizhou 514015, China) |
| Abstract: | A series of benzo［f］chromeno［2,3-d］pyrimidine derivatives were prepared using acetic acid or sodium acetate as catalyst by the condensation cyclization reaction of acetic anhydride and 2-amino-3-cyanobenzo［f］chromene derivatives which were synthesized by the reaction of substitutedbenzoaldehyde, malononitrile and naphthalen-2-ol. This cyclization reaction of 2-amino-3- cyanobenzo［f］chromene derivatives could be finished easily and the product was easily purified, and this method is reported for the first time. |
| Keywords: | benzo［f］chromene derivatives benzo［f］chromeno ［2 3-d］ pyrimidine derivatives |
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