肥大细胞与针刺信息传递机制研究

我们过去的研究表明,在大鼠皮肤中存在多条纵贯全身的交感物质分布线,在这些线上的毛囊立毛肌上分布着极其丰富的交感肾上腺素能神经末梢1-2].大鼠全身剃毛后,新生的毛首先在某些部位优先生长出来,形成新生毛线环路系统1,3-4].针刺或皮内注射药物后会产生立毛运动线,立毛传递线下的皮肤显著充血.这种传递可以在去中枢支配的情况下,独立地沿着交感物质分布线或毛线环路传递,属于邻近毛囊间的连锁或接力传递过程,依赖于通过局部真皮网状层和皮下组织中的神经轴突反射1,5].

A STUDY ON THE ACTION OF MAST CELLS INVOLVING THE MECHANISM OF THE ACUPUNCTURE-PILOMOTER-LINE

On the basis of the previous observed sympathetic-substance lines(SSL),the mechanism of pilomoter line and hyperaemia of the skin after acupuncture in the rats is explored.When the pilomoter line is formed by the hypodermic injection of phenylepherine at SSL,the skin at the line is transversely severed 2-3()cm wide.In the middle of the section below the line,the thickness of the skin increases as a half-moon.It formes by edma in the hypodermis.The skin samples at the line are cut off and sliced by ice-section.The section is dyed with thionin staining and observed by a microscope.The mast cell is specific stained.A lot of granules in the mast cell are being released out.When the rat is injected with sodium cromoglicate(10()mg) to inhibit the release of the mast cell,the subcutaneous injection of phenylepherine can not produce obvious pilomoter line.As a sum,the pilomoter line and the hyperaemia along the SSL is companied with hypodermis edma and formed and /or enhanced by the release of the mast cell.Thus the mast cell must should play very important physiological function in the mechanism of acupuncture and normal states of the body.