磁感应治疗研究和临床试验

 肿瘤磁感应加温治疗是近年来兴起的一项新型肿瘤治疗技术。该技术利用定位导入肿瘤靶区的磁性介质在交变磁场下的磁化损耗产热，对恶性肿瘤实施磁介导加温治疗。研究表明，肿瘤组织在交变磁场诱导的磁热效应下升温至40～70℃时，靶区沉积的热能作用可特异性杀死癌细胞，抑制癌症复发和转移，并可激发机体的抗癌免疫效应，进一步增强治疗效果，是一种简便易行、安全有效的肿瘤治疗方法。磁感应加温治疗在肿瘤治疗的特异性、靶向性等方面显现出其独特优势，已引起了国内外肿瘤临床治疗界的极大兴趣。本文对实验室近年来开展的基于多种磁性介质的肿瘤磁感应热疗研究进行了综述，主要包括磁感应治疗设备研制、热疗用磁性介质研发和磁热疗生物医学实验研究3个方面。在这些研究的基础上，肿瘤磁感应热疗的临床前实验已经完成，目前已经开展一期临床试验研究。

Magnetic Induction Hyperthermia Treatments by Using Multiple Magnetic Materials

The induction heating of magnetic materials implanted into malignant tumors used for magnetic induction hyperthermia is an emerging cancer treatment technology in recent years. It is shown that when a tumor tissue is heated to 40~70℃, the deposited thermal energy has a specific killing effect to cancerous cells and also a preventive effect against tumor formation, recurrence and metastasis. Besides, the hyperthermia treatment can also induce an anticancer immunological function in patients' body, thus further improve the curative effect. With the excellent performance in accuracy of targeting and special treatment effect, the magnetic induction hyperthermia for cancer treatment is drawing more and more attention in clinical antitumor researches. In this paper, the research progress of magnetic induction hyperthermia by using multiple magnetic materials in the laboratory of novel medical technology in Department of Engineering Physics, Tsinghua University is reviewed, including relevant aspects of magnetic field facility developments, magnetic material researches and hyperthermia-related biomedical researches. Further studies of magnetic induction hyperthermia treatment are to be carried out for a plan of Phase-I clinical trials.