| 人参皂苷C-K急性毒性及其致肺水肿作用的研究 |
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| 引用本文： | 刘汉清,陈方芳,苗宁舒,刘志峰.人参皂苷C-K急性毒性及其致肺水肿作用的研究[J].烟台大学学报(自然科学与工程版),2011,24(1). |
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| 作者姓名： | 刘汉清 陈方芳 苗宁舒 刘志峰 |
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| 作者单位： | 1. 烟台大学药学院,山东 烟台,264005
2. 烟台大学药学院,山东 烟台 264005;山东绿叶药物安全评价中心,山东 烟台 264005 |
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| 基金项目： | 山东省科学仪器设备升级改造技术项目 |
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| 摘 要： | 采用灌胃和静脉注射2种给药途径,观察给药1次14 d内小鼠的急性毒性反应;应用人参皂苷C-K(100 mg/kg)复制小鼠肺水肿模型,观察肾上腺素受体阻断剂对其影响;应用肾上腺素复制小鼠肺水肿模型,观察肾上腺素受体阻断剂对其影响.结果表明人参皂苷C-K小鼠口服最大给药量为10.0g/kg,人参皂苷C-K小鼠一次性尾静脉注射,LD50及95 %置信区间为111.707 mg/kg(96.235～ 118.449 mg/kg),其动物死亡主要在5～30 min内,主要表现为急性肺水肿的病理改变.100 mg/kg剂量的人参皂苷C-K可复制典型的小鼠急性肺水肿模型,与肾上腺素所致小鼠肺水肿类似.α-肾上腺素受体阻断剂可减轻人参皂苷C-K致肺水肿,β-肾上腺素受体阻断剂则可加重人参皂苷C-K致肺水肿.
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| 关 键 词： | 人参皂苷C-K 肺水肿 肾上腺素受体 肾上腺素 |
Acute Toxicity of Ginsenoside Compound K and Its Effect on Inducing Lung Edema |
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| LIU Han-qing,CHEN Fang-fang,MIAO Ning-shu,LIU Zhi-feng.Acute Toxicity of Ginsenoside Compound K and Its Effect on Inducing Lung Edema[J].Journal of Yantai University(Natural Science and Engineering edirion),2011,24(1). |
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| Authors: | LIU Han-qing CHEN Fang-fang MIAO Ning-shu LIU Zhi-feng |
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| Institution: | LIU Han-qing1,CHEN Fang-fang1,MIAO Ning-shu1,LIU Zhi-feng1,2(1.School of Pharmacy,Yantai University,Yantai 264005,China,2.Shandong Luye Drugs safty Evaluation Center,China) |
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| Abstract: | Acute toxicity of ginsenoside compound K after intragastric administration and intravenous injection is investigated.Mice lung edema model is prepared by intravenous injection of ginsenoside compound K(100 mg/kg) and the effects of adrenoceptor blocking pharmacons are observed.Mice lung edema model is duplicated by adnephrin induction and the effects of adrenoceptor blocking pharmacons are observed.The results indicates that the maximum dose of ginsenoside compound K to mice by intragastric administration i... |
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| Keywords: | ginsenoside compound K lung edema adrenoceptor adnephrin |
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