| 黄芪等对CP诱发小鼠染色体畸变,SCE和微核的防护作用 |
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| 引用本文： | 邓建云,郭学聪.黄芪等对CP诱发小鼠染色体畸变,SCE和微核的防护作用[J].北京师范大学学报(自然科学版),1992,28(2):221-226. |
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| 作者姓名： | 邓建云 郭学聪 |
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| 作者单位： | 北京师范大学生物系，北京师范大学生物系 100875，北京新外大街，100875，北京新外大街 |
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| 摘 要： | 利用染色体畸变、体内 SCE 技术和微核测定法研究了黄芪、当归和丹参对环磷酰胺(CP)诱变的防护作用.结果表明:黄芪等3种中药本身对小鼠无诱变作用;黄芪、当归对 CP 的诱变有明显防护作用,丹参有一定的防护作用.
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| 关 键 词： | 黄芪 染色体畸变 微核 SCE |
STUDIES ON THE PROTECTION OF ASTRAGALUS MEMBRANACEUS ETC FROM THE CHROMOSOME ABERRATIONS,SCEs AND MICRONUCLEI INDUCED BY CYCLOPHOSPHAMIDE IN MICE |
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| Deng Jianyun Guo Xuecong.STUDIES ON THE PROTECTION OF ASTRAGALUS MEMBRANACEUS ETC FROM THE CHROMOSOME ABERRATIONS,SCEs AND MICRONUCLEI INDUCED BY CYCLOPHOSPHAMIDE IN MICE[J].Journal of Beijing Normal University(Natural Science),1992,28(2):221-226. |
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| Authors: | Deng Jianyun Guo Xuecong |
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| Abstract: | The mutagenicity of three Chinese medicines,Astragalus membranaceus,Angelica sinensis and Salvia miltiorrhiza,and their protection from mutagenesis induced by cyclophosphamide(CP)are studied with in vivo SCE technique,chromosome aberration and micronucleus techniques in mice.The results show that:1)The three Chinese medicines have no mutagenicity to mouse chromosomes;2)A.membranaceus and A.sinensis have obvious protective function on mutagenesis induced by CP and S.miltior- rhiza has some protection.The possible protection mechanisms of the three Chinese medicines to mutagenesis induced by CP are discussed. |
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| Keywords: | Astragalus membranaceus Angelica sinensis Salvia miltiorrhiza cyclophosphamide chromosome aberration sister chromatid exchange micronucleus |
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