Compartmentalized growth of hemopoietic stem cells within mouse Friend leukemic spleens

Summary A dose of 4000 rads (r) to the central portion of mouse spleens followed by Friend erythroleukemic virus infection created independent compartments where hemopoietic stem cells exhibited distinct growth kinetics. Rather than suggesting autonomous proliferation, the stem cell kinetics were indicative of the control excercised by the local microenvironment upon stem cell growth within each compartment.Acknowledgments. This work was supported in part by a grant (014077) from the American Medical Association Eduation and research Foundation, Chicago, Illinois. We also wish to thank Priscilla Brown and Peter Brown for their expertise and patience in preparing the photograph for this report.