线粒体蛋白组研究进展

线粒体蛋白组是指在线粒体中出现的所有蛋白质的集合,包括线粒体自身基因组编码的和 由核基因组编码的蛋白质.线粒体作为真核生物的重要细胞器,它参与去除氧化、产生能量和还原 性物质等等一些重要的生命活动过程.这些功能都依赖于线粒体蛋白组中的蛋白河的相互作用.要 对其有一个较为全面的认识,就必须对其蛋白组进行广泛且深入的研究.根据现有的一些研究成 果,对线粒体蛋白组在起源与进化、跨膜运输、研究方法和计算机预测作了简要综述.

Research progress in mitochondrial proteome

Mitochondrial proteome is all the proteins present in mitochondria, including proteins, encoded by its own genome and nuclear genome. As an important eukaryotic bioenergetic organelle, mitochondria are involved in some important life activities, such as deoxygenation, bioenergetic-producing,reductive matters producing, which are all dependant on their interaction between proteins in mitochondrial proteome. In order to have a comprehensive profile,researchers have been carrying out series of extensive and intensive researches into mitochondrial proteome. According to some results of current researches, this review makes a summary account for origin and evolution, translocation processes,research approaches,bioinformatic prediction with mitochondrial proteome.