T细胞共刺激信号系统研究进展

T细胞是获得性免疫应答的主要识别和效应细胞．T细胞的活化需要两种信号同时存在（即双信号模型，two-signal model）：一是由T细胞受体（TCR）与MHC-抗原肽复合物介导的第一信号，该信号决定了T细胞抗原应答的特异性；二是由表达于T细胞表面的膜蛋白分子及其配体介导的共刺激信号，该信号对于T细胞识别抗原后的完全活化是必须的．共刺激分子的发现为调控T细胞活化及其介导的免疫反应提供了新策略．

The Recent Advances in the Researches of T-cell Co-stimulation

Co - stimulation molecules play key roles in T - cell activation without co - stimulation, T - cell would be rendered to be anery after engagement of antigen peptite - MHC complex with TCR. Blockage of T -cell co- stimulation is potential and promising method to induce immune tolerance in organ transplantation, auto- immunity diseases or other conditions requiring inhibition of immunity. This review covers the recent advances in the research of T - cell co - stimulation, including the members, the expression patterns, the interaction, the working mechanisms and the applications of co - stimulatory stimulation.