| MVD及VEGF表达与鼻咽癌侵袭转移关系的研究 |
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| 引用本文： | 李杰恩,黄光武,唐安洲,徐志文,周永,谭颂华.MVD及VEGF表达与鼻咽癌侵袭转移关系的研究[J].广西科学,2000,7(1):64-66,74. |
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| 作者姓名： | 李杰恩 黄光武 唐安洲 徐志文 周永 谭颂华 |
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| 作者单位： | 广西医科大学第一附属医院耳鼻咽喉科,南宁市滨湖路6号,530021 |
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| 摘 要： | 为探讨微血管密度（ＭＶＤ）及血管内皮生长因子（ＶＥＧＦ）的表达与鼻咽癌（ＮＰＣ）侵袭转移关系，在分子水平干预肿瘤血管生成，预防ＮＰＣ复发和转移打下基础，采用免疫组织化学Ｓ－Ｐ法检测了７３例ＮＰＣ，１５例鼻咽良性肿瘤、２０例无瘤鼻咽部石蜡标本组织中的ＭＶＤ及ＶＥＧＦ表达，ＮＰＣ中转移组４９例，非转移组２４例。
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| 关 键 词： | 鼻咽肿瘤 VEGF MVD 血管生成 肿瘤转移 |
| 收稿时间： | 1999/8/4 0:00:00 |
| 修稿时间： | 1999/11/28 0:00:00 |
MVD and the Expression of VEGF Correlate with Invasion and Metastasis of Nasopharyngeal Carcinoma |
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| Li Jie''en,Huang Guangwu,Tang Anzhou,Xu Zhiwen,Zhou Yong and Tan Songhua.MVD and the Expression of VEGF Correlate with Invasion and Metastasis of Nasopharyngeal Carcinoma[J].Guangxi Sciences,2000,7(1):64-66,74. |
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| Authors: | Li Jie'en Huang Guangwu Tang Anzhou Xu Zhiwen Zhou Yong and Tan Songhua |
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| Institution: | Department of Otolaryngology, the First Affiliated Hospital, Guangxi Medical University, 6 Binhulu, Nanning, Guangxi, 530021, China,Department of Otolaryngology, the First Affiliated Hospital, Guangxi Medical University, 6 Binhulu, Nanning, Guangxi, 530021, China,Department of Otolaryngology, the First Affiliated Hospital, Guangxi Medical University, 6 Binhulu, Nanning, Guangxi, 530021, China,Department of Otolaryngology, the First Affiliated Hospital, Guangxi Medical University, 6 Binhulu, Nanning, Guangxi, 530021, China,Department of Otolaryngology, the First Affiliated Hospital, Guangxi Medical University, 6 Binhulu, Nanning, Guangxi, 530021, China and Department of Otolaryngology, the First Affiliated Hospital, Guangxi Medical University, 6 Binhulu, Nanning, Guangxi, 530021, China |
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| Abstract: | To study the relationship between microvessel density (MVD) and the expression of vascular endothelial growth factor(VEGF) and invasion and metastasis of nasopharyngeal carcinoma(NPC), explore new approaches to prevent NPC from recurrence and metastasis by inhibiting tumors angiogenesis on the molecule level. MVD and the expression of VEGF were detected using immunohistochemical S-P stainning in Paraffin-embedded specimens include 73 patients with NPC and 15 benign nasopharyngeal tumors, 20 tumor-free nasopharyngeal mucosac,MVD and the expression of VEGF in NPC were higher than that of benign nasopharyngeal tumors and tumor-free mucosac(all P<0.01),metastic carcinomas higher than nonmetastic carcinomas(all P<0.05).The expressions of VEGF and MVD were related to the clinical staging. MVD and expression of VEGF may serve as a parameter for determining tumor biological metastatic potential and prognosis. Angiogenesis inhibitors might be helpful in preventing NPC from metastasis. |
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| Keywords: | nasopharyngeal neoplasms vascular endothelial growth factor(VEGF) angiogenesis neoplasms invasion and metastasis |
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