| P物质--甲醛急性刺激效应的分子生物标志物 |
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| 引用本文： | 刘宏亮,童志前,吴江,何胡军,刘军,杨旭.P物质--甲醛急性刺激效应的分子生物标志物[J].华中师范大学学报(自然科学版),2003,37(4):540-543. |
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| 作者姓名： | 刘宏亮 童志前 吴江 何胡军 刘军 杨旭 |
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| 作者单位： | 华中师范大学,生命科学学院,武汉,430079 |
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| 基金项目： | 国家"十五"科技攻关课题(2001BA704B01). |
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| 摘 要： | 分别用0 mg/m3、1 mg/m3、2 mg/m3、3 mg/m3的甲醛对10名受试者进行眼部控制暴露,暴露时间5 min,测定暴露前后鼻腔灌洗液中P物质含量. 结果表明,甲醛暴露后鼻腔灌洗液中P物质含量增加,尤其是3 mg/m3甲醛暴露组P物质含量增加尤为显著(p<0.05). 这说明甲醛刺激眼部三叉神经末梢后,会通过局部轴突反射,引起鼻腔内的三叉神经末梢释放P物质. 因此P物质可作为评价甲醛急性刺激效应的分子生物标志物.
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| 关 键 词： | 甲醛 三叉神经 轴突反射 P物质 鼻腔灌洗液 |
| 文章编号： | 1000-1190(2003)04-0540-04 |
| 修稿时间： | 2003年3月10日 |
Substance P--the biomarker of acute irritation by formaldehyde |
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| LIU Hong-liang,TONG Zhi-qian,WU Jiang,HE Hu-jun,LIU Jun,YANG Xu.Substance P--the biomarker of acute irritation by formaldehyde[J].Journal of Central China Normal University(Natural Sciences),2003,37(4):540-543. |
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| Authors: | LIU Hong-liang TONG Zhi-qian WU Jiang HE Hu-jun LIU Jun YANG Xu |
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| Abstract: | Ten subjects' eyes were exposed to formaldehyde at different doses ((0 mg/m~3,) 1 mg/m~3, 2 mg/m~3, 3 mg/m~3) for five minutes. The content of substance P in the nasal lavage were determined by radio immune assay (RIA). The results showed that the content of substance P increased after exposures, especially during the exposure of 3 mg/m~3 formaldehyde (p<0.05). This maybe explained that formaldehyde could stimulate trigeminal nerve ends of the eyes, which would release substance P from its nasal branches through axon reflex. So we can take the substance P as the molecular biomarker of acute irritation by formaldehyde to investigate the biologic effect of formaldehyde. |
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| Keywords: | formaldehyde trigeminal nerve axon reflex substance P nasal lavage |
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