葛根素对家兔肠系膜微循环的影响

目的：观察葛根素（Puerarin）对家兔动脉血压、心率及其肠系膜微循环的影响。方法：采用微循环研究技术,随机分为正常对照组、微循环障碍组（NE）、微循环障碍改善组（生理盐水组、葛根素组）,观察各组给药前,给药后1、5、10、20、30、60min对微动脉、微静脉的管径、血流速度和血流量变化及动脉血压、心率的变化。结果：葛根素各组给药后均表现出家兔肠系膜微动脉和微静脉血管扩张,血液流速加快,血流量增加（P〈0.05或P〈0.01）,葛根素对家兔动脉血压、心率无显著性影响（P〉0.05）。结论：葛根素能使肠系膜微动脉和微静脉血管扩张、血液流速加快、血流量增加,但对家兔的动脉血压、心率无显著影响。

Effects of Puerarin on Blood Circulation in Rabbits

Objective： To observe the effects of Puerarin （葛根素） on blood pressure, heart rate and mesenteric microeirculation in rabbits. Methods： The changes of indexes on blood presure, heart rate and microcirculation parameters in rabbits were observed by the technique of microcirculation research. Result： Compared with the NE group, the Puerarin group could dilate the arteriole and venule, and increase blood flow velocity and blood perfusion in rabbits （P〈0.05 或 P〈0.01）. Puerarin had no significant effects on blood pressure and heart rate in rabbits （P〉0.05）. Conclution： Puerarin was able to dilate the arteriole and venule, and increase blood flow velocity and blood perfusion obviously.And it also has no obvious effects on blood pressure and heart rate in rabbits.