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| 基因转换的分子机制及其在nrDNA致同进化过程中的应用研究进展 | |
| 引用本文： | 阚显照,王士泉,朱国萍. 基因转换的分子机制及其在nrDNA致同进化过程中的应用研究进展[J]. 科技导报(北京), 2007, 25(9): 47-51 |
| 作者姓名： | 阚显照 王士泉 朱国萍 |
| 作者单位： | 安徽师范大学生命科学学院生物大分子进化重点实验室,安徽芜湖,241000;科技导报社,北京,100081 |
| 基金项目： | 国家自然科学基金项目(30500300)，教育部科学技术研究重点项目(206066)，安徽省引进海外留学人才基金项目(2005Z032) |
| 摘 要： | 基因转换是指同源序列之间非交互性的信息转换。基因转换现象已在原核生物及真核生物中被广泛发现。基因转换的主要作用是引起序列的转移、致同进化、抗原的变异、抗抗生素的免疫、缺口的修复等。通过对引起基因转换现象的4种分子重组模型(Holli-day模型、Meselson-Radding模型、DSBR模型和SDSA模型)的介绍,探讨基因转换在nrDNA致同进化过程中的应用。 |
| 关 键 词： | 基因转换 同源重组 分子机制 nrDNA 致同进化 |
| 文章编号： | 1000-7857(2007)09-0047-05 |
| 修稿时间： | 2007-03-12 |
Progress in Gene Convertion Research: Molecular Mechanisms and the Application in the Process of nrDNA Concerted Evolution |
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| KAN Xianzhao,WANG Shiquan,ZHU Guoping. Progress in Gene Convertion Research: Molecular Mechanisms and the Application in the Process of nrDNA Concerted Evolution[J]. Science & Technology Review, 2007, 25(9): 47-51 | |
| Authors: | KAN Xianzhao WANG Shiquan ZHU Guoping |
| Affiliation: | 1. Key Laboratory of Bio-Micromolecular Evolution, College of Life Science, Anhui Normal University, Wuhu 241000, Anhui Province, China; 2. Science and Technology Review Society, Beijing 100081, China |
| Abstract: | Gene conversion is defined as a non-reciprocal transfer of information between homologous sequences and has been found in a wide variety of karyotic and eukaryotic organisms. It plays an important role in reversion, concerted evolution, antigenic variation, antibiotic resistance and gap repair. Molecular models, including Holliday model, Meselson-Radding model, DSBRmodel, and SDSA model, can be used to explain gene conversion. In this paper, these molecular mechanisms, as well as the role of gene conversion in the process of nrDNA concerted evolution we reviewed. |
| Keywords: | gene conversion homologous recombination molecular mechanisms nrDNA concerted evolution |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |