Local and target-derived actions of neurotrophins during peripheral nervous system development |
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Authors: | Ernfors P |
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Institution: | (1) Laboratory of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institute, 171 77 Stockholm (Sweden), Fax +46 8 341 960, e-mail: patrik@cajal.mbb.ki.se , SE |
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Abstract: | Neurotrophic factors are present in limiting quantities, and neurons that obtain an adequate supply of the required neurotrophic
factor survive whereas those that compete unsuccessfully die. Analysis of null mutant mice for neurotrophins and Trk receptors
as well as in vivo experiments in ovo in the chick applying exogenous neurotrophins or neutralising antisera have significantly
increased knowledge of the roles they play during development. This review focuses on recent advances in understanding the
various roles of neurotrophins in dorsal root ganglion sensory neuron development at different times in embryonic development
- an early local role for differentiation of the sensory precursor cells and a later survival-promoting target-derived role
for the mature neurons. Neurotrophic factors are present in limiting quantities, and neurons that obtain an adequate supply
of the required neurotrophic factor survive whereas those that compete unsuccessfully die. Analysis of null mutant mice for
neurotrophins and Trk receptors as well as in vivo experiments in ovo in the chick applying exogenous neurotrophins or neutralising
antisera have significantly increased knowledge of the roles they play during development. This review focuses on recent advances
in understanding the various roles of neurotrophins in dorsal root ganglion sensory neuron development at different times
in embryonic development - an early local role for differentiation of the sensory precursor cells and a later survival-promoting
target-derived role for the mature neurons. |
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Keywords: | : Neurotrophin nervous system development dorsal root ganglion trophic apoptosis |
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