The role of deubiquitinating enzymes in apoptosis |
| |
Authors: | Suresh Ramakrishna Bharathi Suresh Kwang-Hyun Baek |
| |
Institution: | (1) Department of Biomedical Science, CHA General Hospital, CHA University, 606-16 Yeoksam 1-Dong, Gangnam-Gu, Seoul, 135-081, Republic of Korea; |
| |
Abstract: | It has become apparent that ubiquitination plays a critical role in cell survival and cell death. In addition, deubiquitinating
enzymes (DUBs) have been determined to be highly important regulators of these processes. Cells can be subjected to various
stresses and respond in a variety of different ways ranging from activation of survival pathways to the promotion of cell
death, which eventually eliminates damaged cells. The regulatory mechanisms of apoptosis depend on the balanced action between
ubiquitination and deubiquitination systems. There is a growing recognition that DUBs play essential roles in regulating several
binding partners to modulate the process of apoptosis. Thus, the interplay between the timing of DUB activity and the specificity
of ubiquitin attachment and removal from its substrates during apoptosis is important to ensure cellular homeostasis. This
review discusses the role of a few ubiquitin-specific DUBs that are involved in either promoting or suppressing the process
of apoptosis. |
| |
Keywords: | |
本文献已被 SpringerLink 等数据库收录! |
|