多糖的免疫调节功能研究进展

多糖广泛存在于植物、动物和微生物细胞和细胞壁中,是构成生命的4大基本物质之一,同时也是一类具有免疫调节活性的生物大分子物质,它对机体的特异性和非特异性免疫功能具有增强作用,其作用机制是通过刺激单核-巨噬细胞系统的吞噬功能、促进淋巴细胞增殖和转化、促进抗体生成、诱导细胞因子的分泌、激活补体系统等途径实现对机体免疫系统功能的调节.多糖的生物学活性及其药理作用是国内外科研工作者研究的重要课题之一.文中主要综述了国内外多糖的免疫调节药理作用及其机制的研究概况.

Investigatied Development on Immune Regulation of Polysaccharide

Polysaccharide exists widely in the cell or cell wall of plant, animal, microorganism and epiphyte. As a kind of biologic substance having the action of immune regulation, it can enhance the function of both the nonspecific immunity and the specific immunity. The polysaccharide implements the regulation on immunity system by the following methods : stimulating the function of mononuclear phagocyte system, accelerating the proliferation of lymphocyte, promoting the level of antibody, inducing the exudation of cytokine, activating the complement system, and so on. In the international and domestic research, investigating on the actions of polysaccharide and its pharmacological functions is a primary goal. The pharmacological functions and the mechanism of the polysaccharide immune regulation are summanized.