The effect of guanethidine treatment of testicular blood flow and testosterone production in rats |
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| Authors: | J E Damber |
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| Institution: | Department of Urology and Andrology, University of Ume?, Sweden. |
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| Abstract: | Testicular blood flow was measured by means of Xenon-133 clearance in control rats and rats treated with guanethidine for 3 weeks. Plasma and testis testosterone concentrations were also measured, and the effect of hCG-treatment was examined. No difference in testicular blood flow between the control group and the guanethidine-treated group was found. However, in guanethidine-treated rats, plasma and testis testosterone concentrations after hCG-treatment were significantly decreased. The results may indicate that adrenergic nerves are involved in the regulation of Leydig cell function. |
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