| Synthesis,Structure and Antitumor Activities of [Ni（dien）2][Ni（CN）4] Complex |
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| 摘 要： |
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| 关 键 词： | 合成工艺 抗癌活性 [Ni（dien）2][Ni（CN）4] 晶体结构 多胺 |
| 收稿时间： | 2003-06-13 |
Synthesis,structure and antitumor activities of [Ni(dien)2][Ni(CN)4] complex |
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| Li?Tao,Liang?FengEmail author,Zhang?Shi-wei,Wu?Cheng-tai. Synthesis,structure and antitumor activities of [Ni(dien)2][Ni(CN)4] complex[J]. Wuhan University Journal of Natural Sciences, 2004, 9(2): 229-233. DOI: 10.1007/BF02830608 |
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| Authors: | Li?Tao,Liang?Feng author-information" > author-information__contact u-icon-before" > mailto:chemoliangf@yahoo.com.cn" title=" chemoliangf@yahoo.com.cn" itemprop=" email" data-track=" click" data-track-action=" Email author" data-track-label=" " >Email author,Zhang?Shi-wei,Wu?Cheng-tai |
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| Affiliation: | (1) Department of Ophthalmology, The Affiliated Tongji Hospital, Tongji Medical College of Huazhong University of Science and Technology, 430030 Wuhan, Hubei, China;(2) College of Chemistry and Molecular Sciences, Wuhan University, 430072 Wuhan, Hubei, China;(3) State Key Laboratory for Structural Chemistry of Stable and Unstable Species, Peking University, 100871 Beijing, China |
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| Abstract: | Ni(II)-dien complex was prepared and characterized by X-ray diffraction. The crystal belongs to triclinic system, space group P-1, with crystallographic parametersa=0.888 13(18) nm,b=0.890 10(18) nm,c=1. 591 8(3) nm, α=77.71(3)°, β=89.12(3)°, γ=61.24(3)°,Z=2. The two dien molecules coordinate to the central Ni atom, the six nitrogen atoms form a distorted octahedron. Preliminary pharmacological tests showed this complex had antitumor activity against HepG2 and HL-60 cell linesin vitro. Foundation item, Supported by the National Natural Science Foundation of China (29972034) Biography: Li Tao (1976-), male, Ph. D candidate, research direction: ophthalmology and chemicalbiology. |
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| Keywords: | polyamines Ni(II) complex crystal structure antitumor activity |
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