| 硒葡聚精对小鼠红细胞膜的保护作用 |
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| 引用本文： | 吴凤兰,张明珠,周羽竝,张亚非.硒葡聚精对小鼠红细胞膜的保护作用[J].暨南大学学报,1996(2). |
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| 作者姓名： | 吴凤兰 张明珠 周羽竝 张亚非 |
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| 作者单位： | 暨南大学医学院营养学教研室 |
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| 摘 要： | 以外源性Ｈ２Ｏ２和羟自由基（·ＯＨ）为氧化诱导剂，观察了硒葡聚糖（Ｓｅｌｅｎｉｕｍ—ＧｌｕｃｏｓａｎＳｅ—Ｇｎ）对小鼠红细胞膜氧化损伤的保护作用。结果表明，硒葡聚糖可明显降低Ｈ２Ｏ２诱导的氧化溶血作用，下降率为１１％～２６％。红细胞内脂质过氧化物含量在Ｓｅ—Ｇｎ作用下明显降低。红细胞膜的荧光偏振度（Ｐ）也呈下降趋势，表明红细胞膜流动性增加。实验表明Ｓｅ—Ｇｎ对红细胞的保护作用可能与其参与抗氧化过程有关。
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| 关 键 词： | 硒葡聚糖 红细胞膜 脂质过氧化 荧光偏振 膜流动性 |
The Protective Action of Selenium-Glucosan on Mouce Erythrocyte Membrane |
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| Wu Fenglan, Zhang Mingzhu, Zhou Yubing, Zhang Yafei, Wu Fenglan, Zhang Mingzhu, Zhou Yubing, Zhang Yafei.The Protective Action of Selenium-Glucosan on Mouce Erythrocyte Membrane[J].Journal of Jinan University(Natural Science & Medicine Edition),1996(2). |
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| Authors: | Wu Fenglan Zhang Mingzhu Zhou Yubing Zhang Yafei Wu Fenglan Zhang Mingzhu Zhou Yubing Zhang Yafei |
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| Abstract: | The efface of Selenium--Glucosan on hemolysis and peroxidahon of mouce erythrocytes induced by hydrogenperoxide (H2O2 and hydroxyl radical (.OH) were observed in vitro. The hemolysis,the malonyldialdehyde (MDA) contents and the fluorescence polarization were measured. The results showed that the Selenium--Glucosan could reduce the hemolysis induce by H2O2 and the reduction rate was 11%--26%. The MDA contents of RBC in the Seledum -- Glucosan -- added tubes were decreased significantly. The membrane fiuidity of erythrocyte tended to increase. It was suggested that the protective action of Selenium--Glucosan on erythrocyte ineborace may be concerned with it's antioxidative mechanism. |
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| Keywords: | Selenium-Glucosan erythrocyte membrane lipid peroxidation flourescence polarization membrane fluidity |
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