连续静脉输注硫酸镁在成人重症破伤风治疗中的作用

目的:探讨连续静脉输注硫酸镁治疗成人重症破伤风的有效性和安全性。方法:回顾性分析江汉大学附属医院普外科2000年5月至2010年8月收治的重症破伤风患者共52例,其中使用硫酸镁组27例,未使用硫酸镁组25例。结果:死亡2例,其余50例全部治愈,使用硫酸镁组,镇静剂用量减少、机械通气使用率降低、并发症减少、平均总体费用降低,两组比较差异均有统计学意义(P<0.05),平均住院时间两组比较差异无统计学意义(P>0.05)。结论:硫酸镁可有效控制重症破伤风患者的临床症状,并减少其他镇静剂用量,减少机械通气使用,简化护理程序,并发症少,总体费用低且给药方便。

Role of Continuous Magnesium Sulphate Intravenous Infusion for Treatment of Severe Tetanus of Adults

Objective:To investigate the efficacy and safety of continuous magnesium sulphate intravenous infusion for treatment of severe tetanus of adults.Methods:The clinical data of 52 cases of severe tetanus from May 2000 to August 2010 in the Department of General Surgery of the Affiliat ed Hospital of Jianghan University were analysed retrospectively,the group treated with magnesium sulphate was 27 cases,and the group treated without magnesium sulphate was 25 cases.Results:2 cases died,and the left 50 cases were cured,and in the group treated with magnesium sulphate,the dosage requirement for sedatives reduced,the rate of using ventilatory support reduced,the compli cations reduced,and mean total expense reduced.Compared the two groups,the differenc was statis tically significant(P < 0.05),the difference of mean hospital stays had no statistical significance(P> 0.05).Conclusion:Magnesium sulphate therapy can control the symptom of severe tetanus effective ly,and reduce the dosage requirement for other sedatives,reduce the used of mechanical ventila tion,simplify nursing care,reduce the complications,the total expenses are low,and administra tion is convenient.