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| 含不同立体控制元的手性吡咯酮的合成及其立体化学 | |
| 引用本文： | 黄培强 费向曙. 含不同立体控制元的手性吡咯酮的合成及其立体化学[J]. 厦门大学学报(自然科学版), 1996, 35(6): 913-917 |
| 作者姓名： | 黄培强 费向曙 |
| 作者单位： | 厦门大学化学系 |
| 基金项目： | 国家自然科学基金,国家教委霍英东基金,福建省自然科学基金 |
| 摘 要： | 报道四个带有不同立体控制元的手性吡咯酮的合成．对各种中间体立体化学研究的结果显示，Ｃ－４位上取代基的立体效应和桥连导向作用对Ｃ－５位立体中心的形成起决定性作用，可分别导向反式或顺式产物． |
| 关 键 词： | 2－吡咯烷酮，立体化学，选择性，控制元 |
Synthesis of Chiral Pyrrolidinones Bearing Steric Control Elements |
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| Huang Peiqiang, Fei Xiangshu, Ruan Yuanping,Zhuang Aichang, Chen Ziyang. Synthesis of Chiral Pyrrolidinones Bearing Steric Control Elements[J]. Journal of Xiamen University(Natural Science), 1996, 35(6): 913-917 | |
| Authors: | Huang Peiqiang Fei Xiangshu Ruan Yuanping Zhuang Aichang Chen Ziyang |
| Abstract: | Synthesis of four chiral pyrrolidinones bearing different steric control elements was described. Stereochemical studies on several intermediates showed that the steric effects of C-4 substituents were responsible for high trans stereoselectivity, while the bridging effect arosed from the bonding between C-4 oxygen and nucleophile would direct the nucleophile to approach from the same side as C-4 substituents leading to cis-diastereoisomer. |
| Keywords: | Pyrrolidinone Stereochemistry Selectivity Control element |
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