| 水性聚氨酯/硫酸化壳聚糖复合膜的制备及其血液相容性 |
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| 引用本文： | 王倩,李国明,石光.水性聚氨酯/硫酸化壳聚糖复合膜的制备及其血液相容性[J].华南师范大学学报(自然科学版),2018,50(4):44-47. |
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| 作者姓名： | 王倩 李国明 石光 |
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| 作者单位： | 1.(华南师范大学化学与环境学院,广州 510006) |
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| 基金项目： | 广东高校高分子新型材料产学研结合示范(暨研究生创新培养)基地项目(CGZHZD1007) |
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| 摘 要： | 采用己二异氰酸酯（HDI）三聚体合成了水性聚氨酯（WPU），采用浸渍法将WPU与硫酸化壳聚糖（SCS）通过接枝反应制备出WPU/SCS复合膜. 通过红外光谱、热重分析、差示扫描量热法对复合膜进行了表征，并采用动态凝实验研究了复合膜的血液相容性. 结果表明:WPU与SCS发生了共价结合；复合膜的玻璃化转变温度为53.2 ℃，热分解温度为300~400 ℃；WPU/SCS复合膜的血液相容性优于水性聚氨酯. 因此WPU/SCS复合膜是具有潜力的生物医用材料.
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| 关 键 词： | 水性聚氨酯 硫酸化壳聚糖 复合膜 血液相容性 |
| 收稿时间： | 2016-12-21 |
Synthesis and Hemocompatibility of WPU/SCS Composite Membrane |
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| Institution: | 1.(School of Chemistry and Environment,South China Normal University,Guangzhou 510006,China) |
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| Abstract: | The waterborne polyurethane (WPU) was synthesized by using trimers of 1,6-hexamethylene diisocyanate(HDI). WPU film was dipped in solution of sulfated chitosan (SCS) to prepare WPU/SCS composite films. The obtained films were characterized by FT-IR, TGA and DSC. The hemocompatibility of the composite membrane was studied by dynamic coagulation test. The results showed that the WPU was combined with SCS through covalent bonds,that the composite membrane had a Tg of 53.2 ℃ and a thermal decomposed temperature of 300-400 ℃,and that the composite membrane had better hemocompatibility than WPU. WPU/SCS composite membrane is a potential biomedical material. |
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