佛手挥发油对小鼠体内B16黑色素瘤生长的影响

观察了佛手挥发油对小鼠体内B16黑色素瘤生长的影响．以B16黑色素瘤细胞感染小鼠建立动物肿瘤模型，设正常对照组、阴性对照组和阳性对照组及佛手挥发油低、中、高剂量组，各组荷瘤小鼠予以相应的药物实施干涉14d，每天观察各组荷瘤小鼠的肿瘤生长情况，14d后测定荷瘤小鼠的心、肝、肾中超氧化物歧化酶（SOD）活性和丙二醛（MDA）含量．与阴性对照组相比，50mg／kg剂量佛手挥发油能显著抑制雌性荷瘤小鼠移植瘤的增殖（P〈0．05），显著提高其肝脏中SOD活性（P〈0．01）．表明佛手挥发油对B16移植瘤具有抑制作用．

The effect of fingered citron volatile oil on mouse B16 melanoma growing in vivo

It was observed the effect of fingered citron volatile oil on melanoma growing in mice.Infected mice with B16 cells were used to establish tumor animal model.It was set up normal control group,negative control group and positive control group,and low,medium and high dose fingered citron volatile oil group.Each mice group bearing-melanoma were intervened with corresponding drug for 14 days,and observed tumor growth cases of each group every day.14 days later,it was measured the enzyme activity of SOD and the content of MDA of hearts,livers and kidneys.To female bearing-melanoma mice,compared with the negative group mice,50 mg/kg dose fingered citron volatile oil dramatically inhibited the proliferation of transplanted tumor(P<0.05),and significantly improved the enzyme activity of SOD(P<0.01).It showed that fingered citron volatile oil had inhibitory effect on B16 transplanted tumor.