Fifty years of amanitin. |
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Authors: | T Wieland H Faulstich |
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Institution: | Max-Planck-Institut für Medizinische Forschung, Heidelberg, Germany. |
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Abstract: | Pharmacokinetic studies have provided new insights into human Amanita poisoning, but it appears to be impossible to treat this intoxication by immunotherapy. New synthetic analogs have revealed structure-activity relationships that were unknown so far. The main toxin, alpha-amanitin, is in constant use as a tool in molecular biology and in biological research. First experiments have been reported in which amanitin bound to polymers could be internalized into tumor cells via a receptor-mediated endocytosis. |
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