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| 新型雌激素受体ERα36与窖蛋白-1在皮肤组织细胞中的表达和分布特征 | |
| 引用本文： | 邹伟,朱焱,马依妮,赵春晖,宋智琦,刘晶,王兆一.新型雌激素受体ERα36与窖蛋白-1在皮肤组织细胞中的表达和分布特征[J].辽宁师范大学学报(自然科学版),2012,35(2):241-245. |
| 作者姓名： | 邹伟 朱焱 马依妮 赵春晖 宋智琦 刘晶 王兆一 |
| 作者单位： | 1. 辽宁师范大学生命科学学院,辽宁大连116081;辽宁省生物技术和分子药物研发重点实验室,辽宁大连116081 2. 辽宁师范大学生命科学学院,辽宁大连,116081 3. 大连医科大学附属第一医院中英再生医学临床研究中心,辽宁大连,116011 4. Creighton大学癌症研究中心,美国68178 |
| 摘 要： | 采用蛋白免疫印迹杂交和免疫细胞荧光等方法首次研究了新型雌激素受体ERα36和窖蛋白-1（Caveolin-1）在大鼠皮肤组织中以及角质细胞系中的表达,探讨了二者的表达关系和分布特征.结果发现：（1）大鼠皮肤中有ERα36的表达,其表达的量与Caveolin-1的表达量呈负相关,且存在性别差异和部位差异;（2）表皮角质细胞中有ERα36的表达,主要分布在细胞膜上,且与Caveolin-1共定位.提示新型雌激素受体ERα36存在于皮肤细胞中,且可能参与Caveolin-1介导的雌激素信号转导,在雌激素治疗皮肤疾病过程中发挥一定作用. |
| 关 键 词： | 雌激素受体ERα36 小窝蛋白Cav-1 皮肤细胞 |
Expression and distribution of a novel variant estrogen receptor alpha 36 and caveolin-1 in skin cells |
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| ZOU Wei , ZHU Yan , MA Yi-ni , ZHAO Chun-hui , SONG Zhi-qi , LIU Jing , WANG Zhao-yi.Expression and distribution of a novel variant estrogen receptor alpha 36 and caveolin-1 in skin cells[J].Journal of Liaoning Normal University(Natural Science Edition),2012,35(2):241-245. | |
| Authors: | ZOU Wei ZHU Yan MA Yi-ni ZHAO Chun-hui SONG Zhi-qi LIU Jing WANG Zhao-yi |
| Institution: | 1.College of Life Science,Liaoning Normal University,Dalian 116081,China; 2.Liaoning Key Laboratories of Biotechnology and Molecular Drug R&D,Dalian 116081,China; 3.Regenerative Medicine Centre,First Affiliated Hospital of Dalian Medical University,Dalian 116011,China; 4.Cancer Center,Creighton University,NE 68178,USA) |
| Abstract: | In order to study on the expression and distribution of a novel estrogen receptor ERα36 in skin tissues of rats and keratinocytes,Western blot and immunoflourescence were performed.Result showed that(1)ERα36 is expressed in the skin of rats,and the relationship between amount of ERα36 and Caveolin-1 is negative correlation,the amount of difference not only in gender but also in tissue;(2) ERα36 is expressed in keratinocytes,and partly co-localized on the cell membrane with Caveolin-1.It suggested that ERα36 may participate in the estrogen signal pathway mediated by Caveolin-l and plays an important role in the process of estrogen treatment on skin. |
| Keywords: | estrogen receptor alpha 36 Caveolin-1 skin ce11s |
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