| 番茄红素改善D-半乳糖致衰老大鼠抗氧化功能的研究 |
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| 引用本文： | 裴凌鹏,惠伯棣,董福慧,王永志.番茄红素改善D-半乳糖致衰老大鼠抗氧化功能的研究[J].首都师范大学学报(自然科学版),2007,28(3):67-70. |
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| 作者姓名： | 裴凌鹏 惠伯棣 董福慧 王永志 |
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| 作者单位： | 1. 中国中医科学院,北京,100700
2. 北京联合大学应用文理学院生物系,北京,100083 |
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| 摘 要： | 用D-半乳糖注射Wistar雄性大鼠5个月,建立衰老模型.对青年对照组、正常老龄对照组、模型组、高/中/低不同剂量番茄红素组血清MDA含量、肝脏匀浆MDA含量和血液SOD、GSH-Px酶活性进行测定及比较.实验结果表明青年对照组和番茄红素组血清MDA含量和肝脏匀浆MDA含量均比模型组有显著降低（P＜0.01）,而血液SOD、GSH-Px酶活性比模型组有显著升高（P＜O.01）.因此摄入适量番茄红素可以有效地增强大鼠机体抗氧化能力,从而延缓D-半乳糖诱发的大鼠衰老.
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| 关 键 词： | 丙二醛 超氧化物歧化酶 谷胱甘肽过氧化酶 番茄红素 |
| 修稿时间： | 2006-06-12 |
Effects of Lycopene on Antioxidantive Action in D-Galactose Induced Aged Rat |
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| Pei Lingpeng,Hui Bodi,Dong Fuhui,Wang Yongzhi.Effects of Lycopene on Antioxidantive Action in D-Galactose Induced Aged Rat[J].Journal of Capital Normal University(Natural Science Edition),2007,28(3):67-70. |
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| Authors: | Pei Lingpeng Hui Bodi Dong Fuhui Wang Yongzhi |
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| Institution: | 1 China Academy of Chinese Medicine Science, Beijing 100700; 2 College of Applied Art and Science of BUU, Beijing 100083 |
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| Abstract: | To cause aging,Wistar rats were given injections of D-galactose for 5 months.They were randomly divided in four groups,including model group,lycopene groups(low-dose group,middle-dose group and high-dose group).At the same time,young control group and old control group were setup.The content of serum MDA,liver MDA and the activity of SOD and GSH-Px of all gr6ups,which were tested and compared.Experimental results that the content of serum MDA,liver MDA in young group and lycopene group were significantly decreased(P<0.01),compared with model group.However,the activity of SOD and GSH-Px was significantly raised(P<0.01).Therefore lycopene can increase antioxidantive function of rat to stay D-galactose induced consenescence. |
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| Keywords: | SMDA SOD GSH-Px Lycopene |
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