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| 5-{4-[2-(甲基-2-吡啶氨基)-乙氧基]-亚苄基}-4-硫代-2,4-噻唑烷二酮的合成 | |
| 引用本文： | 朱微,余爱农. 5-{4-[2-(甲基-2-吡啶氨基)-乙氧基]-亚苄基}-4-硫代-2,4-噻唑烷二酮的合成[J]. 湖北民族学院学报(自然科学版), 2012, 0(1): 23-26 |
| 作者姓名： | 朱微 余爱农 |
| 作者单位： | 湖北民族学院化学与环境工程学院 |
| 基金项目： | 国家自然科学基金项目(20876036) |
| 摘 要： | 以2-氯吡啶为原料,经过取代反应、威廉森反应、劳森反应和缩合反应合成了5-{4-[2-(甲基-2-吡啶氨基)-乙氧基]-亚苄基}-4-硫代-2,4-噻唑烷二酮,4步反应的收率分别为65.49%、63.68%、68.83%和85.48%.中间体和目标化合物经MS、IR和1H-NMR确证是预期的化合物. |
| 关 键 词： | 糖尿病 4-硫代-2,4-噻唑烷二酮 劳森反应 合成 |
Synthesis of 5-{4-[2-(N-Methyl-N-(2-pyridinyl)amino)-ethoxy]-benzylidene}-4-thioxo-2,4-thiazolidinone |
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| ZHU Wei,YU Ai-nong. Synthesis of 5-{4-[2-(N-Methyl-N-(2-pyridinyl)amino)-ethoxy]-benzylidene}-4-thioxo-2,4-thiazolidinone[J]. Journal of Hubei Institute for Nationalities(Natural Sciences), 2012, 0(1): 23-26 | |
| Authors: | ZHU Wei YU Ai-nong |
| Affiliation: | *(School of Chemical and Environmental Engineering,Hubei University for Nationalities,Enshi 445000,China) |
| Abstract: | The 5-{4-[2-(N-Methyl-N-(2-pyridinyl)amino)-ethoxy]-benzylidene}-4-thioxo-2,4-thi-azolidinone has been synthesized by substitution reaction,Williamson reaction,Lawesson′s reaction and condensation reaction,with 2-chloropyridine as starting material.The four-step reaction yield is 65.49%,63.68%,68.83% and 85.48% respectively.The intermediates and target compounds are expected compounds by MS,IR and 1H-NMR conclusive evidence. |
| Keywords: | Diabetes 4-thioxo-2,4-thiazolidineones lawesson′s reaction synthesis |
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