一种三苯基有机锡配合物的晶体结构及抗癌活性

以三苯基氢氧化锡为底物, 酰亚胺酸(HL)为配体, 制备新型配合物(Ph₃Sn)(L)·C₁₂H₆O_3（配合物1）, 并用元素分析、 X 射线单晶衍射、 红外光谱及核磁共振等方法对其组成和结构进行表征, 用噻唑蓝（MTT）法测试该配合物的抗癌活性. 实验结果表明： 配合物1的晶体结构属单斜晶系, P21/c空间群, 晶胞参数a=2238 50(17) nm, b=1202 30(14) nm, c=1441 0(3) nm,  α=90000(0)°, β=101217(2)°, γ=90000(0)°, V=3804 1(9) nm3, Z=4, Dc=1509 g/cm3; 配合物1为单体结构, 中心金属Sn原子通过与配体羧基中O原子的配位, 形成配位数为4的 扭曲四面体几何配位构型, 在配合物1的晶体结构中, 配合物上的配体与游离萘酐分子间存在π…π相互作用; 配合物1对癌细胞MCF-7和Hepg2均具有较强的抑制作用.

Crystal Structure and Antitumor Activity ofa Triphenyl Organotin Complex

A new complex (Ph3Sn)(L)·C₁₂H₆O₃ (complex 1) wasprepared with triphenyltin hydroxide as substrate and amide acid as ligand. Its composition and structure were characterized by elemental analysis, X ray single crystal diffraction, infrared spectroscopy and nuclear magnetic resonance, and the antitumor activity of the complex was tested by MTT assay. The experimental results show thatthe crystal structure of complex 1 belongs to monoclinic syngonyand P21/c space group. The cell parameters are as follows: a=2238 50(17) nm, b=1202 30(14) nm, c =1441 0(3) nm, α=90000(0)°, β=101217(2)°, γ=90.000(0)°, V=3804 1(9) nm3, Z=4, Dc= 1.509 g/cm3. The complexl is a monomer structure. The central Sn atom coordinates with O atom in theligand carboxyl group to form a distorted tetrahedral geometric coordination configuration with coordination number 4. In the crystal structure of complex 1, there is π…π interaction betwwen ligand and freeanhydride naphthalene molecule. The complex 1 has strong inhibitory effect on cancer cells MCF-7 and Hepg2.