Persistent inverse maternal effect on corticosterone production in vitro |
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| Authors: | P R W Wood J G M Shire |
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| Institution: | (1) Institute of Genetics, University of Glasgow, Glasgow, Scotland;(2) Department of Biology, University of Essex, C04 3SQ Colchester, England |
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| Abstract: | Summary Adrenal cells from C57BL/Tb mice produced more steroid than those from DBA/2J mice. Reciprocal differences between both backcross and F1 hybrids showed a persistent maternal effect. Mothers with high output produce offspring with reduced hormone production when adult. Corticosterone output thus depends on maternal phenotype as well as on the genotype of the isolated cells.We thank Margaret MacKendrick for her help and the Medical Research Council for a research studentship for PRWW. |
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| Keywords: | Adrenals corticosterone maternal effects stress inbred strains mice |
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