Acidic metabolite of prednisolone |
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| Authors: | H J Lee |
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| Institution: | (1) School of Pharmacy, Florida Agricultural and Mechanical University, 32307 Tallahassee, Florida, USA |
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| Abstract: | Summary The metabolic fate of the 17 -ketol side chain of (21-3H) prednisolone was studied with an enzyme preparation from male golden hamster liver. The acidic metabolite of prednisolone was identified by mass spectrometry as 11, 17 ,20 -trihydroxy-3-oxo-1,4-pregnadien-21-oic acid. The enzyme showed substrate specificity, depending on the nature of substituent on the steroid nucleus.This investigation was supported in part by USPHS Grant CA 2515. |
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