G蛋白偶联受体研究进展

G蛋白偶联受体（GPCRs）是体内最大的蛋白质超家族，根据结构的同源性，主要分为A、B、C3族．GPCRs配体的多样性决定配体结合域的多样性．受体分子内相互作用力的破坏、质子化、构象改变、与G蛋白的偶联及受体二聚化参与了GPCRs的活化过程，近年发现GPCRs的失敏和内吞对受体功能调节亦非常重要，本文拟综述以上内容的研究进展．

Research Development of G Protein- coupled Receptors

G Protein-coupled Receptors(GPCRs) are maximal protein-superfamily in body which composed of A, B and C three family on the basis homdogy of the construction. Multiplicity of GPCRs ligand decide on Multiplicity of ligand combine-field. They are concernced with activation process of GPCR_s that are destory of interactional force in receptor,protonate, conformation be changed, coupled with G protein or receptor dimerization. Recently, desensitization and ligand of GPCRs play an important role in adjust of recepeor function. Progress in the study of these content are reviewed in this paper.