配合物与G-四链体DNA相互作用的研究

端粒在维持基因组稳定、癌症和衰老相关的生理过程中发挥着重要作用,鸟嘌呤通过形成G-四分体平面堆积成G-四链体结构,DNA二级结构参与一些重要的生物调控过程。人们已经在生物体内发现G-四分体结构的存在,它们大量存在于基因的启动区域表明G-四链体可能参与调节基因表达。以G-四链体为新靶标设计能与G-四链体DNA相互作用的小分子,为开发抗癌药物提供了新途径。最近的许多研究证明金属配合物与G-四链体DNA具有有效的相互作用,有望开发成新的抗癌药物。

Interaction of Metal Complexes with G-quadruplex DNA

Telomeres play an important role in critical physiological processes, including genome stability, cancer, and aging. G - quadruplex DNA is a four - stranded structure that is held together by square planes of G - quartets. Guanine - rich sequences with the potential to form G - quadruplexes exist in the telomere as well as in promoter regions of certain oncogenes. The identifi- cation of these sequences as novel targets for the development of anticancer drugs has sparked interest in the design of molecules that can interact with quadruplex DNA. Numerous metal complexes have recently been shown to interact effectively with G - quadruplexes. This review provides an overview of the important roles that metal complexes can play as quadruplex DNA binding molecules. The detection of G - quadruplex DNA is an important target for developing potential antitumor drugs.