| 雌二醇对缺氧－复氧心肌电机械变化的保护作用 |
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| 引用本文： | 马季骅,王亚非,张玉芹,张培华.雌二醇对缺氧－复氧心肌电机械变化的保护作用[J].武汉科技大学学报(自然科学版),1996(4). |
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| 作者姓名： | 马季骅 王亚非 张玉芹 张培华 |
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| 摘 要： | 采用同步记录豚鼠右心室乳头肌细胞跨膜电位和收缩力ＦＣ的方法，观察了雌二醇（３．３ｎｇ／ｍＬ）对缺氧－复氧心室肌电机械活动的影响。结果表明，雌二醇使缺氧豚鼠心室肌细胞动作电位时程和有效不应期相对延长，收缩力ＦＣ相对增大，并能显著抑制缺氧－复氧引起的迟发后除极和触发激动。说明雌二醇对缺氧－复氧心肌电机械变化具有保护作用。
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| 关 键 词： | 雌二醇 乳头肌 缺氧 跨膜电位 心肌收缩 迟发后除极 |
PROTECTIVE EFFECT OF ESTRADIOL ON ELECTRICAL AND MECHANICAL CHANGES IN REPERFUSED VENTRICULAR MUSCLES |
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| Ma Jihua Wang Yafei Zhang Yuqing Zhang Peihua.PROTECTIVE EFFECT OF ESTRADIOL ON ELECTRICAL AND MECHANICAL CHANGES IN REPERFUSED VENTRICULAR MUSCLES[J].Journal of Wuhan University of Science and Technology(Natural Science Edition),1996(4). |
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| Authors: | Ma Jihua Wang Yafei Zhang Yuqing Zhang Peihua |
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| Institution: | Ma Jihua Wang Yafei Zhang Yuqing Zhang Peihua |
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| Abstract: | Effect of estradiol(3.3ng/ml) on electrical and mechanical activities were observed by means of synchronous recording of transmembrane potential and contractial force ( F C ) in reperfused guinea pig papillary muscles. Results showed that estradiol prolonged action potential duration and effective refractory period, strengthened F C in hypoxia ventricular muscles and inhibited remarkably delayed afterdepolarization and triggered activity in reperfused ventricular muscles. It was suggested that estradiol has a protective effect on electrical and mechanical changes in reperfused ventricular muscles. |
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| Keywords: | estradiol papillary muscles hypoxia transmembrane potential triggered activity |
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