| ［5－（4－甲脒－苄基）－2，4－二氧代－咪唑烷－3－基］－乙酰基－L－天冬氨酰－L－缬氨酸的合成 |
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| 引用本文： | 陈安黎,陈维新.［5－（4－甲脒－苄基）－2，4－二氧代－咪唑烷－3－基］－乙酰基－L－天冬氨酰－L－缬氨酸的合成[J].华东理工大学学报(自然科学版),1995(4). |
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| 作者姓名： | 陈安黎 陈维新 |
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| 作者单位： | 德国达姆斯塔特工业专科大学，华东理工大学 |
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| 摘 要： | 根据由精氨酸－甘氨酸－天冬氨酸组成的肽能抑制血小板聚集的机制，设计并合成了［５－（４－甲脒－苄基）－２，４－二氧代－咪唑烷－３－基］－乙酰基－Ｌ－天冬氨酰－Ｌ－缬氨酸（９）。生物试验结果表明：（９）抑制血小板聚集作用最强，其活性以ＩＣ＿（５０）值相比，强于类似物。
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| 关 键 词： | 肽，天冬氨酰，缬氨酸，抗血小板聚集，4－甲脒基苯丙氨酸 |
Synthesis of [5-(4-Formamidino-Benzyl)-2,4-Dioxo-Imidazolidin-3-yl]-Acetyl-L-Aspartyl-L-Valin(9) |
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| Chen Anli.Synthesis of [5-(4-Formamidino-Benzyl)-2,4-Dioxo-Imidazolidin-3-yl]-Acetyl-L-Aspartyl-L-Valin(9)[J].Journal of East China University of Science and Technology,1995(4). |
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| Authors: | Chen Anli |
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| Abstract: | According to the mechanism of the inhibiting action of peptlue Arg-Gly-Asp onplatelet aggregation. Peptide(9)was designed and synthesized.Results of biologic tests showedinhibiting action of(9)on platelet aggregation was the most potent.Its activity was strongerthan that of analogues in comparison with that of IC_(50). |
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| Keywords: | peptide aspartyl valin inhibition of platelet aggregation 4-formamidino-phery-lalanine |
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