| 无关供者骨髓移植治疗多次复发性急性白血病 |
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| 引用本文： | 刘元生,苏永忠,郭光华,陈惜遂,陈芾珩,卢素春,庄春兰.无关供者骨髓移植治疗多次复发性急性白血病[J].汕头大学学报(自然科学版),2003,18(1):39-42. |
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| 作者姓名： | 刘元生 苏永忠 郭光华 陈惜遂 陈芾珩 卢素春 庄春兰 |
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| 作者单位： | 汕头大学医学院第一附属医院,汕头,515041 |
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| 摘 要： | 文章探讨无关供者骨髓移植治疗多次复发急性白血病的疗效 .经改良 Bucy方案预处理后对一例第三次复发的急粒患者行无关供者骨髓移植 ,同时给防治 GVHD、抗感染治疗 .结果 + 2 1天骨髓在患者体内植活 ,+ 35天细胞染色体分析呈供者型 ( 4 6,XX.正常核型 ) ,+ 84天血型转换成供者型 ,至今已无病生存超过 6个月 .结果表明 ,无关供者骨髓移植对多次复发的急性白血病患者具有治疗价值
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| 关 键 词： | 无关供者 骨髓移植 白血病 多次复发 |
| 文章编号： | 1001-4217(2003)01-0039-04 |
| 修稿时间： | 2002年4月28日 |
Unrelated Donor Bone Marrow Transplatation in Treatment of Multiple Relapse Acute Leukemia |
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| Liu Yuansheng,Su Yongzhong,Guo Guanghua,Chen Xisui,Chen Fuheng,Lu Suchun,Zhuang Chunlan.Unrelated Donor Bone Marrow Transplatation in Treatment of Multiple Relapse Acute Leukemia[J].Journal of Shantou University(Natural Science Edition),2003,18(1):39-42. |
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| Authors: | Liu Yuansheng Su Yongzhong Guo Guanghua Chen Xisui Chen Fuheng Lu Suchun Zhuang Chunlan |
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| Abstract: | In this paper is evaluated the effect of a modified Bucy regimen for unrelated donor bone marrow transplantation on the patients with multiple relapse acute leukemia. A case with the third recurrence of granulocytic leukemia, after due pretreatment in accordance with the modified Bucy regimen, was transplanted with bone marrow from unrelated donor, along with administration of proper medicines for prevention against GVH disease and infection. Cytogenetic studies have demonstrated successful engraftment of bone marrow at the 21st day, the presence of donor chromosome(46,XX)at the 35th day, and a survival period more than 6 months without any disease. It is concluded that unrelated donor bone marrow transplantation is an efficacious therapeutic for the patients with recurrent acute leukemia. |
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| Keywords: | unrelated donor bone marrow transplantation leukemia multiple relapse |
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