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The complexity of mitogen-activated protein kinases (MAPKs) made simple
Authors:M. Krishna  H. Narang
Affiliation:(1) Radiation Biology and Health Sciences Division, Bhabha Atomic Research Centre, Mumbai, 400085, India
Abstract:
The mitogen-activated protein kinase (MAPK) pathways are known to be involved in various processes of growth, differentiation and cell death. In spite of their ubiquitous presence and seemingly enormous cross-talk with each other, their action is very specific. This review deals with various aspects of the three different MAPK pathways (ERK, p38 and JNK) and how their specificity is brought about. Received 1 April 2008; received after revision 18 June 2008; accepted 18 June 2008
Keywords:. Mitogen-activated protein kinase  activation  phosphorylation  specificity  ERK  p38  JNK
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