Ultrastructural study of somatotroph cells from mice bearing a fast growing transplanted hepatoma,in different periods of the tumor development

Summary The presence of a transplanted, fast-growing hepatoma (SS1-K) produces conspicuous ultrastructural changes in pituitary STH cells of C3H-S male mice. These changes are suggestive of an increased secretion of growth hormone only during the first stages of the tumor development. The hepatoma influence does not seem to be clearly related to the illumination regimen or time of killing.Acknowledgments. The authors wish to thank Miss G. Neira for technical assistance.