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Frequent mutations of chromatin remodeling genes in transitional cell carcinoma of the bladder |
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| Authors: | Gui Yaoting Guo Guangwu Huang Yi Hu Xueda Tang Aifa Gao Shengjie Wu Renhua Chen Chao Li Xianxin Zhou Liang He Minghui Li Zesong Sun Xiaojuan Jia Wenlong Chen Jinnong Yang Shangming Zhou Fangjian Zhao Xiaokun Wan Shengqing Ye Rui Liang Chaozhao Liu Zhisheng Huang Peide Liu Chunxiao Jiang Hui Wang Yong Zheng Hancheng Sun Liang Liu Xingwang Jiang Zhimao Feng Dafei Chen Jing Wu Song Zou Jing Zhang Zhongfu Yang Ruilin Zhao Jun Xu Congjie Yin Weihua Guan Zhichen Ye Jiongxian Zhang Hong Li Jingxiang Kristiansen Karsten Nickerson Michael L Theodorescu Dan Li Yingrui Zhang Xiuqing Li Songgang |
| Affiliation: | Guangdong and Shenzhen Key Laboratory of Male Reproductive Medicine and Genetics, Institute of Urology, Peking University Shenzhen Hospital, Shenzhen PKU-HKUST Medical Center, Shenzhen, China. |
| Abstract: | Transitional cell carcinoma (TCC) is the most common type of bladder cancer. Here we sequenced the exomes of nine individuals with TCC and screened all the somatically mutated genes in a prevalence set of 88 additional individuals with TCC with different tumor stages and grades. In our study, we discovered a variety of genes previously unknown to be mutated in TCC. Notably, we identified genetic aberrations of the chromatin remodeling genes (UTX, MLL-MLL3, CREBBP-EP300, NCOR1, ARID1A and CHD6) in 59% of our 97 subjects with TCC. Of these genes, we showed UTX to be altered substantially more frequently in tumors of low stages and grades, highlighting its potential role in the classification and diagnosis of bladder cancer. Our results provide an overview of the genetic basis of TCC and suggest that aberration of chromatin regulation might be a hallmark of bladder cancer. |
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