Analysis for gene networks based on logic relationships |
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| Authors: | Shudong Wang Yan Chen Qingyun Wang Eryan Li Yansen Su Dazhi Meng |
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| Affiliation: | (1) UCLA-DOE Institute for Genomics and Proteomics, University of California Los Angeles, Los Angeles, CA, USA;(2) Department of Molecular, Cell, and Developmental Biology, University of California Los Angeles, Los Angeles, CA, USA;(3) Department of Chemistry and Biochemistry, University of California Los Angeles, Los Angeles, CA, USA;(4) Howard Hughes Medical Institute, University of California Los Angeles, Los Angeles, CA 90095, USA |
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| Abstract: | The reverse construction and analysis of the networks of molecular interactions are essential for understanding their functions within cells. In this paper, a logic network model is constructed to investigate the complicated regulation mechanism of shoot genes of Arabidopsis Thaliana in response to stimuli. The dynamics of the complicated logic network is analyzed, discussed, and simulated. The simulation results show that the logic network of the active genes of shoot eventually evolves into eleven attractors under the stimuli, including five 1-periodic and six 2-periodic attractors. Our work provides valuable reference and guidance for biologists to understand and explain Arabidopsis’ response to external stimuli by experiments. |
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