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| 手性衍生化试剂MTPEA酰胺衍生物的合成 | |
| 引用本文： | 姚立红 苏长安. 手性衍生化试剂MTPEA酰胺衍生物的合成[J]. 辽宁大学学报(自然科学版), 1996, 23(3): 45-53 |
| 作者姓名： | 姚立红 苏长安 |
| 作者单位： | [1]辽宁大学化学系 [2]辽宁大学分析测试中心 |
| 摘 要： | 本文报导了手性衍生化试剂ＭＴＰＥＡ酰胺衍生物的合成方法。Ｄ，Ｌ－２甲氧基－２－三氟甲基－２－苯基乙胺（ＭＴＰＥＡ）与十个光学活性羧酸在二环已基碳二亚胺（ＤＣＣ）的存在下直接反应；分别生成等量的非对映异构酰胺。通过ＩＲ、＾１Ｈ ＮＭＲ、＾１３Ｃ ＮＭＲ、ＭＳ及元素分析等方法测定了各酰胺的结构。此外，还讨论了酰胺分子在质谱中的裂解方式。 |
| 关 键 词： | 合成 酰胺衍生物 试剂 手性衍生化试剂 MTPEA |
Synthesis of the Amide Derivatives of Chiral Derivatizing Agent MTPEA |
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| Yao Lihong. Synthesis of the Amide Derivatives of Chiral Derivatizing Agent MTPEA[J]. Journal of Liaoning University(Natural Sciences Edition), 1996, 23(3): 45-53 | |
| Authors: | Yao Lihong |
| Abstract: | The synthetic method of the amide derivatives of chiral derivatizing agent MTPEA is described. Ten eqUimolar diastereomeric amides were prepared separately by the direct reactions of D, L -2-methoxy-2-trifluoromethyl-2-phenylethylamine(MTPEA) with ten optically active carboxylic acids in the presence of N, N'-dicyclohexyl-carbodiimide(DCC). The structures of all products were determined by methods of IR; 1H NMR; 13C NMR; MS and 'elemental analysis. And the fragmentation pathways of the amides in Mass spectrometry(EI ) were discussed. |
| Keywords: | Optically active carboxylic acid Diastereomeric amide synthesis and fragmentation pathway. |
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