| 以天然冰片为手性源的α-取代乳酸的不对称合成 |
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| 引用本文： | 葛军英,周国斌,刘芳,宋新鲁,罗国强,陈慧宗. 以天然冰片为手性源的α-取代乳酸的不对称合成[J]. 江西师范大学学报(自然科学版), 2006, 30(5): 447-449 |
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| 作者姓名： | 葛军英 周国斌 刘芳 宋新鲁 罗国强 陈慧宗 |
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| 作者单位： | 1. 江西师范大学,化学化工学院,江西,南昌,330027
2. 山东科技大学,化学与环境工程学院,山东,青岛,266510 |
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| 基金项目： | 国家自然科学基金;江西省自然科学基金 |
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| 摘 要： | 以天然丰产的冰片为手性源与非手性的丙酮酸进行酯化反应生成手性丙酮酸冰片酯,该酯与格氏试剂进行Grignard反应,选择性地得到指定构型过量的α-取代乳酸.
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| 关 键 词： | 天然冰片 手性源 丙酮酸 不对称合成 α-取代乳酸 |
| 文章编号： | 1000-5862（2006）05-0447-03 |
| 收稿时间： | 2006-01-11 |
| 修稿时间： | 2006-01-11 |
Natural Chiron Borneol Applied in α- Substitution Lactic Acid Asymmetric Synthesis |
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| GE Jun-ying,ZHOU Guo-bin,LIU Fang,SONG Xin-lu,LUO Guo-qiang,CHEN Hui-zong. Natural Chiron Borneol Applied in α- Substitution Lactic Acid Asymmetric Synthesis[J]. Journal of Jiangxi Normal University (Natural Sciences Edition), 2006, 30(5): 447-449 |
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| Authors: | GE Jun-ying ZHOU Guo-bin LIU Fang SONG Xin-lu LUO Guo-qiang CHEN Hui-zong |
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| Affiliation: | 1. Institute of Chemistry and Chemical Engineering Sciences,Jiangxi Normal University, Nanchang 330027, China; 2. College of Chemistry and Environmental Engineering, Shandong Univeristy of Science and Technology, Qindao Shandong 266510, China |
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| Abstract: | Esterification with natural abundant chiron borneol and achiral pyruvic acid is studied,the resultant is chiral bornyl pyruvate,the ester reacts with Grignard reagent.That is to say,this is stereospecitic reaction.The product is excessly specified configuration alpha-substitution lactic acid. |
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| Keywords: | natural borneol chiral source pyruvic acid asymmetric synthesis alpha-substitution lactic acid |
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