Th17细胞调节宿主免疫应答功能研究进展

T细胞诱导的特异性免疫应答是机体血液淋巴细胞特异性免疫应答的重要组成部分,Th17细胞作为第3类因子可区分于体液中其他辅助T细胞.基于此,论述了Th17细胞系在对抗胞外寄生和胞内寄生细菌以及真菌感染中的作用.一系列研究表明,Th17细胞系能够紧密联系固有免疫和特异性免疫,使机体产生强烈的感染炎症反应.Th17细胞系既能...

Research Progress of the Functions of Th17 Cells in Host Defence

Lineage-specific responses from the effector T-cell repertoire form a critical component of adaptive immunity.The recent identification of Th17 cells—a third,distinct lineage of helper T cells—collapses the long-accepted paradigm in which Th1 and Th2 cells distinctly mediate cellular and humoralimmunity respectively.In this mini review,we discuss the involvement of the Th17 lineage during infection by extracellular bacteria,intracellular bacteria,and fungi.Emerging trends suggest that the Th17 population bridges innate and adaptive immunity to produce a robust antimicrobial inflammatory response.However,because Th17 cells mediate both host defense and pathological inflammation,elucidation of mechanisms that attenuate but do not completely abolish the Th17 response may have powerful implications for therapy.