猪胸膜放线杆菌中黏附素的研究进展

胸膜肺炎放线杆菌(Actinobacillus pleuropneumoniae,APP)是引起猪传染性胸膜肺炎疾病的病原菌,APP引起猪致病的毒力因子有多种,其中黏附素作为细菌粘附宿主的第一步中的关键作用被广泛关注.黏附是APP感染宿主的第一步,分泌到革兰氏阴性菌表面的自转运黏附索调节着细菌对宿主细胞的黏附,是重要的...

Research Progress on Autotransporter Adhesins of Actinobacillus pleuropneumoniae in Pigs

The pathogenic bacteria of the pleuropneumonia in swine is the Actinobacillus pleuropneumoniae which has many toxic factors.Adhere to host cell is the first step of bacteria which is the key function of adhesin,and has been paid extensively attention.An ability of bacterial proteins to promote adhesion to biological surfaces is a fundamental step in bacterial infections.Autotransporter adhesion,which is secreted to the surface of Gram-negative bacteria,is important virulence factors and mediates adherence to eukaryotic cells.In this article,we review our current knowledge of the strutural and functional characteristics of autotransporter adhesion,highlighting a potential of autotransporter adhesion as targets for the design of novel vaccines directed against Gram-negative pathogens.