| 铂(II)与胺类配合物的合成、晶体结构和抗肿瘤活性研究 |
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| 引用本文： | 潘勇军,夏军,杜勇,朱海亮*.铂(II)与胺类配合物的合成、晶体结构和抗肿瘤活性研究[J].武汉科技学院学报,2003(2). |
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| 作者姓名： | 潘勇军 夏军 杜勇 朱海亮* |
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| 作者单位： | 武汉科技学院环境与化学工程系 湖北武汉430073
(潘勇军，夏军，杜勇)，武汉科技学院环境与化学工程系 湖北武汉430073(朱海亮*) |
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| 基金项目： | 武汉科技学院资助项目 (项目编号:023068). |
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| 摘 要： | 研究铂(II)与三种胺类配合物的合成、晶体结构和体外抗肿瘤活性,化合物1的X-射线单晶结构分析表明:这是一个很少见的具有四方锥几何构型的铂(II)配合物,顺式平面四方形配位的铂的轴向上有第5个配位原子。其抗肿瘤活性实验显示3个配合物对几种研究的癌细胞都有较强的抑制作用。
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| 关 键 词： | 铂(II)配合物 抗肿瘤活性 晶体结构 细胞毒性 |
Synthesis,Crystal Structure and Antitumor Activity of Platinum(II) Complexes |
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| PAN Yong-jun,XIA Jun,DU Yong,ZHU Hai-liang.Synthesis,Crystal Structure and Antitumor Activity of Platinum(II) Complexes[J].Journal of Wuhan Institute of Science and Technology,2003(2). |
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| Authors: | PAN Yong-jun XIA Jun DU Yong ZHU Hai-liang |
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| Abstract: | Three Cis-Platinum (II) complexes of amines (L) have been prepared and structurally characterized and activity determined, where L is hexamethlene-diamine, hexamethylene-tetramine and pyridine. Crystal structure of Pt(H2O)3Cl(C6H12N4)]Cl was determinated by x-ray single analysis, indicating that it is a cis-compound. The result of antitumor activity assay indicated that complexes 1~3 strongly inhibit the growth of several human solid carcinoma cell lines. Their anti-tumor activities are possibly related to the amount and the emplacement of Pt(II) in the complexes. |
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| Keywords: | Pt (II) complexes crystal structure anti-tumor activity cytotoxity |
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