| 心肌灌注显像剂99mTc-替曲膦的制备与应用 |
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| 引用本文： | 虞燕华,罗世能,沈永嘉,陈志明,汪洋.心肌灌注显像剂99mTc-替曲膦的制备与应用[J].华东理工大学学报(自然科学版),2006,32(12):1445-1448. |
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| 作者姓名： | 虞燕华 罗世能 沈永嘉 陈志明 汪洋 |
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| 作者单位： | 1. 江苏省原子医学研究所,无锡,214063
2. 华东理工大学精细化工研究所,上海,200237 |
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| 摘 要： | 亚磷酸三乙酯与1,2二-溴乙烷的加成产物经L iA lH4还原得乙二膦,后者与乙烯基乙醚发生加成反应生成1,2双-双(2乙-氧基乙基)膦基]乙烷(替曲膦),这是一种新型的心肌灌注显像剂99mT c替-曲膦的配体,产物及中间产物经IR、1H-NMR、M S得到确证。用SnC l2将99mT cO-4还原成99mT cO2] 后与替曲膦反应得到99mT c替-曲膦,其放射化学纯度为93%。临床使用表明:制得的99mT c替-曲膦能够满足临床显像要求,且标记简便。
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| 关 键 词： | 乙二膦 乙烯基乙醚 心肌灌注显像剂 双膦化合物 99mTc-替曲膦 |
| 文章编号： | 1006-3080（2006）12-1445-04 |
| 收稿时间： | 2006-01-16 |
| 修稿时间： | 2006年1月16日 |
Preparation and Application of Myocardial Perfusion Imaging Agent 99mTc-Tetrofosmin |
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| YU Yan-hua,LUO Shi-neng,SHEN Yong-jia,CHEN Zhi-ming,WANG Yang.Preparation and Application of Myocardial Perfusion Imaging Agent 99mTc-Tetrofosmin[J].Journal of East China University of Science and Technology,2006,32(12):1445-1448. |
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| Authors: | YU Yan-hua LUO Shi-neng SHEN Yong-jia CHEN Zhi-ming WANG Yang |
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| Abstract: | Tetraethyl ethylenediphosphonate was synthezised by reaction of triethyl phosphite with(1,2-)dibromoethane.It was reduced by lithium aluminum hydride to generate(1,2-)Bis(phosphino)-ethane.1,2-bisbis(2-ethoxyethyl)phosphino] ethane(tetrofosmin) produced from the reaction of 1,2-bis(phosphino)-ethane with ethyl vinyl ether.Tetrofosmin is the ligand of()~(99m)Tc-tetrofosmin,which is a novel(myocardial) perfusion imaging agent.Products of each reaction were characterized by IR,()~1H-NMR and(MS.Tetrofosmin) was radiolabelled by ()~(99m)TcO_2]~ ,obtained from the reaction of()~(99m)TcO~-_4 with SnCl_2,to(afford()~(99m))Tc-tetrofosmin,which met the requirements in the clinical trial. |
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| Keywords: | 1 2-bis(phosphino)ethane ethyl vinyl ether myocardial perfusion imaging agent bisphosphonate ~(99m)Tc-tetrofosmin |
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