| 血啉甲醚-光动力学疗法去除大鼠前列腺增生的实验研究 |
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| 引用本文： | 陈杰波,许小平,欧敏锐,谢俊.血啉甲醚-光动力学疗法去除大鼠前列腺增生的实验研究[J].福州大学学报(自然科学版),2005,33(4):545-548. |
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| 作者姓名： | 陈杰波 许小平 欧敏锐 谢俊 |
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| 作者单位： | 福州大学化学化工学院,福建,福州,350002 |
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| 摘 要： | 以丙酸睾酮诱导的大鼠前列腺增生为研究对象,观察光动力学疗法(PDT)对大鼠前列腺增生的治疗作用.研究结果表明:单纯激光照射或单纯注射光敏剂对大鼠前列腺增生无显著影响(P>0.05);大鼠经各PDT治疗组治疗后,前列腺体积均明显减小,前列腺指数明显下降,与动物模型组存在明显差异(P均小于0.01),说明光动力疗法对前列腺增生细胞具有杀伤和抑制生长作用.
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| 关 键 词： | 血啉甲醚 光动力学疗法 大鼠 前列腺增生 光敏剂 |
| 文章编号： | 1000-2243(2005)04-0545-04 |
| 修稿时间： | 2004年10月20 |
Effect of photodynamic therapy using HMME on benign prostatic hyperplasia in rats: a preliminary experimental investigation |
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| CHEN Jie-bo,XU Xiao-ping,OU Min-rui,XIE Jun.Effect of photodynamic therapy using HMME on benign prostatic hyperplasia in rats: a preliminary experimental investigation[J].Journal of Fuzhou University(Natural Science Edition),2005,33(4):545-548. |
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| Authors: | CHEN Jie-bo XU Xiao-ping OU Min-rui XIE Jun |
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| Institution: | (College of Chemistry and Chemical Engineering, Fuzhou University, Fuzhou, Fujian 350002, China) |
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| Abstract: | Used the rat model of benign prostatic hyperplasia (BPH) as the object, observing morphological changes in cells of the prostate of the rates after photodynamic therapy (PDT). The results revealed that index numbers of prostate (PI) of the group that just treated by laser and the group that just injected with photosensitizer hematoporphyrin monomethyl ether (HMME) were similar to that of model group (P>0.05). And the PI of the PDT group was obviously decreased compared with the model group (P<0.01). It is indicated that selective injurious effect and growth suppressing effect of PDT on prostatic hyperplasia cells, and PDT with HMME could be an alternative approach to the treatment of BPH. |
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| Keywords: | HMME photodynamic therapy rats benign prostatic hyperplasia photosensitizer |
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