Synthesis and antibacterial activities of selenide derivatives of Benzisoselenazolone |
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Authors: | Yang Li-ping wu jun Peng Yun-shan Liu Xiu-fang Xu Han-sheng |
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Institution: | (1) College of Chemistry and Molecular, Wuhan University, 430072 Wuhan, China |
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Abstract: | A series of Benzisolselenazolone (BISA) derivatives were synthesized and evaluated for their antibacterial activities againstE coli. by using LKB-2277 bioactivity monitor. Other bioactivities were tested by the method of High Throughput Screening for pharmaceutical
activity compounds (HTP) BISA derivatives 3b, at the concentration of 40 μg/mL, showed 100% antibacterial activity and 62%
inhibition rate of aldose reductase (at the concentration of 5μg/mL). These new compound structures have determined by IR,1H NMR and MS spectra.
Foundation item: Supported by Hubei Province Natural Science Fund (99J056)
Biography: Yang Li-ping (1975-), female, Master, research direction: organic seleno-compound, antioxidation medicines, selenium-enriched
garlic. |
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Keywords: | BISA Ebselen antibacterial activity NO synthase Aldose reductase |
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