| 杂色曲霉转化孕酮的研究 |
| |
| 引用本文： | 杨海英,李忠孝,沈广剑,张振宇,李淑娟,杜刚.杂色曲霉转化孕酮的研究[J].云南民族大学学报(自然科学版),2015(2):126-128. |
| |
| 作者姓名： | 杨海英 李忠孝 沈广剑 张振宇 李淑娟 杜刚 |
| |
| 作者单位： | 云南民族大学民族药资源化学国家民族事务委员会-教育部重点实验室 |
| |
| 基金项目： | 云南省教育厅科学研究基金重点项目(2013Z038);云南民族大学化学与生物技术学院SRT项目(2013HXSRT05) |
| |
| 摘 要： | 利用杂色曲霉对孕酮进行生物转化,通过HPLC对转化产物进行检测,硅胶柱层析分离纯化转化产物,得到3个转化产物.运用NMR、MS、IR等波谱数据对转化产物进行结构鉴定,确定转化产物结构为:雄烯二酮(AD);睾酮;雄二烯二酮(ADD).研究结果表明,杂色曲霉菌株能够裂解孕酮C-17位的侧链,生成19个碳的转化产物,并对裂解产物进行结构修饰.
|
| 关 键 词： | 生物转化 杂色曲霉 孕酮 结构鉴定 |
Biotransformation of progesterone by Aspergillus versicolor |
| |
| YANG Hai-ying;LI Zhong-xiao;SHEN Guang-jian;ZHANG Zhen-yu;LI Shu-juan;DU Gang.Biotransformation of progesterone by Aspergillus versicolor[J].Journal of Yunnan Nationalities University:Natural Sciences Edition,2015(2):126-128. |
| |
| Authors: | YANG Hai-ying;LI Zhong-xiao;SHEN Guang-jian;ZHANG Zhen-yu;LI Shu-juan;DU Gang |
| |
| Institution: | YANG Hai-ying;LI Zhong-xiao;SHEN Guang-jian;ZHANG Zhen-yu;LI Shu-juan;DU Gang;Key Laboratory of Chemistry in Ethnic Medicinal Resources,State Ethnic Affairs Commission and Ministry of Education of China,School of Chemistry and Biotechnology,Yunnan Minzu University; |
| |
| Abstract: | Progesterone was transformed by Aspergillus versicolor and three transformation products were obtained.These products were elucidated by13 C NMR,1H NMR,FTIR and MS. The structures of these compounds were androstenedione,testosterone and androstanedienedione. The results showed that the progesterone could be split at C-17 by Aspergillus versicolor. |
| |
| Keywords: | biotransformation Aspergillus versicolor progesterone structural identification |
| 本文献已被 CNKI 等数据库收录！ |
