Growth inhibitory,insecticidal and antifeedant effects of some antileukemic and cytotoxic quassinoids on two species of agricultural pests |
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| Authors: | J. A. Klocke M. Arisawa S. S. Handa A. D. Kinghorn G. A. Cordell N. R. Farnsworth |
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| Affiliation: | (1) Plant Resources Institute, University Research Park, 84108 Salt Lake City, Utah, USA;(2) Program for Collaborative Research in the Pharmaceutical Sciences, College of Pharmacy, Health Sciences Center, University of Illinois at Chicago, 60612 Chicago, Illinois, USA;(3) Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, 833 S. Wood Street, 60612 Chicago, Ill, USA |
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| Abstract: | ![]()
Summary Several quassinoids, obtained by isolation and derivatization fromSimaba multiflora andSoulamea soulameoides, were evaluated for growth inhibitory and insecticidal effects against the tobacco budworm (Heliothis virescens) and for antifeedant effects againstH. virescens and the fall armyworm (Spodoptera frugiperda). The relative activity of the quassinoids as insect growth inhibitors generally paralleled their known relative potency as antileukemic and cytotoxic agents.Phytochemical aspects of this work were supported by Contract CM-97295 with the Division of Cancer Treatment, National Cancer Institute, National Institutes of Health, Bethesda, Md. Insects were kindly supplied by the agency of the United States Department of Agriculture at Brownsville, TX. |
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| Keywords: | Quassinoids Heliothis virescens Spodoptera frugiperda growth inhibitory effects antifeedant effects antileukemic activity cytotoxic activity |
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