| 粉红丝带引发的思考——Wnt信号通路在乳腺发育与乳腺癌变中的角色 |
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| 引用本文： | 俞清,曾艺.粉红丝带引发的思考——Wnt信号通路在乳腺发育与乳腺癌变中的角色[J].科技导报(北京),2016,34(20):5-13. |
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| 作者姓名： | 俞清 曾艺 |
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| 作者单位： | 中国科学院上海生命科学研究院生物化学与细胞生物学研究所, 细胞生物学国家重点实验室, 上海 200031 |
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| 摘 要： | Wnt信号转导通路是参与乳腺发育和肿瘤形成的重要机制。本文综述了Wnt信号转导通路调控乳腺发育和干细胞稳态研究的进展，讨论了Wnt信号转导中成员分子在乳腺癌形成中的角色。
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| 收稿时间： | 2016-09-11 |
Mammary development and breast cancer: A Wnt prospective |
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| YU Qing,ZENG Yi.Mammary development and breast cancer: A Wnt prospective[J].Science & Technology Review,2016,34(20):5-13. |
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| Authors: | YU Qing ZENG Yi |
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| Institution: | State Key Laboratory of Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China |
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| Abstract: | The Wnt pathway has emerged as a key signaling cascade participating in mammary organogenesis and breast oncogenesis. This paper reviews the current knowledge of how the pathway regulates the stem cells and the normal development of the mammary gland, and how its various components contribute to the breast carcinoma pathology. |
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| Keywords: | Wnt mammary organogenesis stem cells breast carcinoma |
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