| TIMP-4 mRNA在小鼠子宫中的表达和激素调节 |
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| 引用本文： | 卜淑敏,汪建红.TIMP-4 mRNA在小鼠子宫中的表达和激素调节[J].新疆师范大学学报(自然科学版),2008,27(1):97-100. |
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| 作者姓名： | 卜淑敏 汪建红 |
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| 作者单位： | 1. 首都体育学院,北京,100088
2. 新疆师范大学,生命科学与化学学院,新疆,乌鲁木齐,830054 |
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| 摘 要： | 为研究TIMP-4 mRNA在子宫中的变化规律，采用半定量RT-PCR方法，观察了TIMP-4 mRNA在出生后小鼠子宫不同发育期、动情周期、妊娠早期以及假孕早期子宫中的表达和激素调节。结果发现，TIMP-4 mRNA在出生后不同发育期的小鼠子宫中、动情周期的任何时期、妊娠第1天以及假孕第1天的子宫中都不表达，但在妊娠和假孕第2天、第3天、第4天的子宫中都表达。以上结果提示，TIMP-4 mRNA在妊娠小鼠子宫中的表达可能不依赖存活胚胎的激活，而可能受母体妊娠分泌物的上调。
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| 关 键 词： | TIMP-4 小鼠 子宫 表达和调节 |
| 文章编号： | 1008-9659-(2008)-01-0097-03 |
| 修稿时间： | 2007年8月28日 |
Expression and Hormonal Regulation of Tissue Inhibitor of Metalloproteinase-4 in Mouse Uterus |
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| BU ShuMin,WANG Jianhong.Expression and Hormonal Regulation of Tissue Inhibitor of Metalloproteinase-4 in Mouse Uterus[J].Journal of Xinjiang Normal University(Natural Sciences Edition),2008,27(1):97-100. |
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| Authors: | BU ShuMin WANG Jianhong |
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| Institution: | BU Shumin , WANG Jianhong (1. Capital Institute of Physic Education, Beijing 100088 ; 2. College of Life Science and Chemistry, Xinjiang Normal University, Urumqi Xinjiang 830054) |
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| Abstract: | The tissue inhibitor of metalloproteinase-4 （TIMP-4） is the newest member of TIMP family and its function in the reproductive system remains unclear. In the present study, semi-quantitative RT-PCR was used to investigate its expression in mice uteri during postpartum period, the estrous cycle, early pregnancy and early psypregnancy. The results showed that TIMP-4 mRNA was not detected in mouse uterus during postpartum period and estrus cycle day 1 of pregnancy or day 1 of psypregnancy, but it could be detected only in the pregnancy day 2, 3,4 as well as the psypregnancy day 2, 3, 4, 5. These data suggested that TIMP-4 mRNA in uterus might be activated by materials derived from mother rather than embryo. |
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| Keywords: | TIMP-4 mice uterus expression and regulation |
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